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目的了解辽宁省本溪市手足口病流行现状及病原学特征,及时掌握手足口病流行规律和趋势。方法对2012—2015年本溪市手足口病资料进行分析,采用逆转录PCR方法进行病毒核酸检测。结果 2012—2015年本溪市共报告手足口病病例2 276例,年均发病率为33.23/10万,无重症和死亡病例。病例高发期在6-9月份;发病年龄主要为1~5岁,病例以托幼儿童和散居儿童为主,男性高于女性。2012—2015年共检测1 105例手足口病标本,检出阳性标本659例,阳性检出率为59.64%。阳性标本中,CoxA16型、EV71型、CoxA16型和EV71型混合感染及其他肠道病毒的构成比分别为28.83%、21.40%、2.73%和47.04%,病原构成呈动态变化。结论2012—2015年本溪市手足口病发病存在明显的时间、地区、年龄、性别和职业差异,发生的手足口病主要由CoxA16和EV71型病毒引起,是EV71型和CoxA16型为主混合型感染地区,目前逐渐向以其他肠道病毒为主混合型感染地区转变。
Objective To understand the prevalence and etiological characteristics of HFMD in Benxi City of Liaoning Province and to grasp the prevalence and trend of HFMD. Methods The data of HFMD in Benxi City from 2012 to 2015 were analyzed, and the viral nucleic acid was detected by reverse transcription PCR. Results A total of 2 276 cases of hand, foot and mouth disease were reported in Benxi City from 2012 to 2015, with an average annual incidence of 33.23 / 100 000, with no serious or death cases. High incidence of cases in the 6-9 months; age of onset is mainly 1 to 5 years old, mainly in kindergarten children and diaspora children, men than women. A total of 1 105 cases of hand, foot and mouth disease were detected in 2012-2015. A total of 659 positive samples were detected, the positive rate was 59.64%. The positive rates of CoxA16, EV71, CoxA16 and EV71 and other enteroviruses were 28.83%, 21.40%, 2.73% and 47.04%, respectively. The pathogen showed a dynamic change. Conclusion The incidence of hand, foot and mouth disease in Benxi City in 2012-2015 was significantly different with time, region, age, gender and occupation. Hand-foot-mouth disease was mainly caused by CoxA16 and EV71 viruses, and was mainly mixed EV71 and CoxA16 Region, and now gradually to other enterovirus-based mixed infection areas change.