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HIV—1选择性地感染表达CD4分子的细胞,引起AIDS病患者CD4T细胞在数量和功能上的缺损。然而,患者外周血中只有很少量的细胞在任何时候都表达HIV—1。原有的研究表明,在试管中HIV—1感染CD4~+T细胞时可引起CD4表达的减弱,在感染细胞的表面不再能检测到CD4蛋白。在AIDS患者外周血中表达病毒RNA的频率一般为1/10万～1/万个
HIV-1 selectively infects CD4-expressing cells and causes CD4 T cells in AIDS patients to have quantitative and functional deficits. However, only a very small amount of cells in peripheral blood of patients express HIV-1 at any time. Previous studies showed that HIV-1 infected CD4 ~ + T cells in the test tube caused a decrease in CD4 expression and no longer detectable CD4 on the infected cells. The frequency of viral RNA expression in the peripheral blood of AIDS patients is typically 1/10 million to 1/10 000