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目的:探讨硫酸锌灌肠对溃疡性结肠炎的治疗价值、方法:31例溃疡性结肠炎患者随机分为对照组和治疗组,对照组给予SASP1.0qid加利多卡因100mg,庆大霉素24万单位,地塞米松10mg灌肠,治疗组采用sASP1.0qid加硫酸锌250mg灌肠,每日一次,疗程二周。内镜检查观察疗效。检测治疗前后血清锌含量并与正常人比较。结果:溃疡性结肠炎患者血清锌含量明显低于正常人群(P<0.01),治疗组患者的近期治愈率明显高于对照组(P<0.05),治疗组治疗前后血清锌含量变化有显著性差异(P<0.01)。结论:血清锌的测定可作为诊断溃疡性结肠炎的参考指标之一,硫酸锌灌肠对溃疡性结肠炎有较好的治疗作用。
Objective: To investigate the therapeutic value of zinc sulfate enema on ulcerative colitis. Methods: Thirty-one patients with ulcerative colitis were randomly divided into control group and treatment group. The control group was given SASP1.0qid plus lidocaine 100mg, gentamycin 24 Million units of dexamethasone 10mg enema, the treatment group with sASP1.0qid plus zinc sulfate 250mg enema, once daily for two weeks. Endoscopy to observe the effect. Serum zinc levels were measured before and after treatment and compared with normal people. Results: The levels of serum zinc in patients with ulcerative colitis were significantly lower than those in normal people (P <0.01). The cure rates in the treatment group were significantly higher than those in the control group (P <0.05), and the changes of serum zinc in the treatment group before and after treatment were significant Difference (P <0.01). Conclusion: The determination of serum zinc can be used as a reference index in the diagnosis of ulcerative colitis. Zinc sulfate enema has a good therapeutic effect on ulcerative colitis.