论文部分内容阅读
目的:观察不同剂量辛伐他汀治疗老年高血脂患者疗效与安全性。方法:将纳入研究的80例老年高血脂患者随机分为高剂量组和低剂量组,各40例。高剂量组给予辛伐他汀剂40 mg/日,低剂量组给予20 mg/日。治疗2个月后观察疗效、血脂水平变化情况,并统计两组不良反应的发生情况。结果:高剂量组总有效率95%显著高于低剂量组的80%(P<0.05);治疗后,两组TG、TC、LDL-C、HDL-C水平均有改善,与本组治疗前比较均有显著性差异(P均<0.05),且高剂量组上述指标改善明显优于低剂量组(P均<0.05);治疗期间两组不良反应发生率无统计学意义(P>0.05)。结论:辛伐他汀高剂量(40 mg/日)治疗老年高血脂的疗效优于低剂量(20 mg/日),且不增加不良反应发生的风险。
Objective: To observe the efficacy and safety of different doses of simvastatin in elderly patients with hyperlipidemia. Methods: Eighty elderly hypertriglyceridemic patients were randomly divided into high dose group and low dose group, 40 in each. Simvastatin 40 mg / day was given in the high-dose group and 20 mg / day in the low-dose group. After 2 months of treatment, the curative effect and blood lipid level were observed, and the occurrence of adverse reactions in both groups were also calculated. Results: The total effective rate of high dose group was 95%, which was significantly higher than that of low dose group (P <0.05). After treatment, the levels of TG, TC, LDL-C and HDL- (P <0.05), and the improvement of the above indexes in the high-dose group was obviously better than that in the low-dose group (all P <0.05). There was no significant difference in adverse reactions between the two groups during the treatment (P> 0.05 ). Conclusion: Simvastatin at a high dose (40 mg / day) is superior to low dose (20 mg / day) in the treatment of elderly hyperlipidemia without increasing the risk of adverse reactions.