NO和心肾血管病

• 作 者: 牟善初
• 机 构: 解放军总医院,
• 出 处: 国外医学(老年医学分册)
• 发表日期: 1995年03期
• 关键词: 一氧化氮合成酶 心肾 血管病 NO 合成酶抑制剂 肾血管疾病 精氨酸 动物实验 防御机制 高血压模型

一氧化氮(NO)这一气体性传递及调节介质,被称为1992年“明星分子”。它由细胞内的NO合成酶催化L-精氨酸生成。NO合成酶分为构成型和诱导型。前者参与血压的调节、神经的传导,后者参与防御机制。动物实验证实NO合成酶抑制剂可使血压升高。NO的吸入治疗在原发性及继发性肺动脉高压、ARDS的治疗上均有作用。本文简述了NO及其抑制剂在心肾血管疾病中的一些作用。

Nitric oxide (NO), a gaseous mediator and mediator, is called the “star” of 1992. It is catalyzed by intracellular NO synthase L-arginine. NO synthase is divided into constitutive and inducible. The former involved in the regulation of blood pressure, nerve conduction, the latter involved in the defense mechanism. Animal experiments confirmed that NO synthase inhibitors can raise blood pressure. Inhaled NO treatment in primary and secondary pulmonary hypertension, ARDS have a role in the treatment. This article describes some of the roles of NO and its inhibitors in cardiovascular and renal disease.