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低镁血症是顺铂使用中常见的毒性反应。其发病率和严重性与剂量有关，一般为40～100％，但仅10％的病人有症状和体征，而且多数较轻或与其他联合化疗的药物毒性相混淆而被人忽视。产生低镁血症的原因，主要是肾小管对镁的重吸收减低，使镁从尿中流失。在用顺铂后同时测量血清和尿的电解质，可以看到镁是在血清中缺乏的情况下，唯一的在尿中仍排出的电解质，因此有人认为镁的损失可能是特殊膜与运输系统的缺陷所造成。
Hypomagnesemia is a common toxic reaction in cisplatin use. Its morbidity and severity are dose-related, typically 40-100%, but only 10% of patients have symptoms and signs and are mostly neglected or confused with the toxicity of other combination chemotherapies. The cause of hypomagnesemia, mainly tubular reabsorption of magnesium to reduce the loss of magnesium from the urine. After measuring the electrolytes of serum and urine simultaneously with cisplatin, it can be seen that magnesium is the only electrolyte still excreted in the urine in the absence of serum, so it is thought that the loss of magnesium may be due to the special membrane and transport system Caused by defects