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目的:分析甘氨双唑钠对放射治疗食管癌增敏作用的临床效果。方法:依照相应的标准查找文献、资料,进而对对符合条件的RCT进行资料提取和质量评价后,采用Review manager 5软件进行Meta分析。结果:纳入研究的18组对象中,分析食管癌患者的近期疗效,发现苷氨双唑钠联合放疗效果由于单纯放疗,数据符合统计学差异(P<0.05);同时在提高患者1年与2年生存率方面,甘氨双唑钠联合放疗效果显著于单纯放疗,数据符合统计学差异(P<0.05);且甘氨双唑钠联合放疗不会增加患者黏膜反应、抑制骨髓、放射性肺炎以及放射性食管炎等不良反应。结论:相对于单纯的放疗治疗食管癌,甘氨双唑钠联合放疗近期疗效较为显著,同时可提高患者生存率,而脸和放疗的安全性与患者生活质量,还需进一步论证。
Objective: To analyze the clinical effect of glycididazol on the sensitization of esophageal cancer to radiation therapy. Methods: According to the corresponding criteria to find the literature and data, and then to the qualified RCT data extraction and quality evaluation, using Review manager 5 software for meta-analysis. Results: 18 patients included in the study, the recent treatment of esophageal cancer patients and found that glycosaminidazol combined with radiotherapy due to radiotherapy alone, the data were statistically significant (P <0.05); at the same time improve the patients 1 year and 2 Annual survival rate, glycopyrrolate sodium combined with radiotherapy significantly in the radiotherapy alone, the data were statistically significant (P <0.05); and glycopyrrolate sodium combined with radiotherapy does not increase the patient’s mucosal response, inhibition of bone marrow, radiation pneumonitis and Radiation esophagitis and other adverse reactions. CONCLUSIONS: Compared with simple radiotherapy for esophageal cancer, glycopyrrolate sodium combined with radiotherapy has a relatively short-term curative effect, and at the same time it can improve the survival rate of patients, while the safety of face and radiotherapy and the quality of life of patients need to be further demonstrated.