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目的对男性不育患者进行染色体核型的检测,以指导其生育。方法1.应用规范的WHO精液检查方法检查男性不育患者精液标本。2.应用细胞遗传学检测男性不育患者外周血染色体核型分析。结果1.精液检查结果:男性不育组患者356例,包括无精子症82例、严重少精子症126例、少弱精子症148例,精液正常、核型正常男性组对照50例。2.细胞染色体检查:356例男性不育患者全部进行外周血淋巴细胞染色体核型分析,发现55例染色体核型异常,包括性染色体异常24例,常染色体异常21例和染色体多态性10例。其中,无精子症组的染色体异常率25.61%(21/81),严重少精子症患者染色体核型异常率为11.90%(15/126),少弱精子症患者染色体核型异常率为12.84%(19/148)。结论男性不育患者核型异常率为15.45%,远高于正常人群发病率。细胞遗传学染色体检查对男性不育的生育指导有重要意义。无精子症患者进行染色体检查尤其必要。
Objective To detect chromosomal karyotype in male infertility patients to guide their fertility. Method 1. Application of standardized WHO semen examination methods to check male infertility patients semen samples. Cytogenetics analysis of male infertility patients with peripheral blood chromosome karyotype analysis. Results 1. Semen examination results: Male infertility group of 356 patients, including 82 cases of azoospermia, 126 cases of severe oligospermia, 148 cases of oligozoospermia, normal sperm normal control group of 50 patients. 2. Cell chromosome examination: 356 cases of male infertility patients with peripheral blood lymphocyte chromosome karyotype analysis found 55 cases of karyotype abnormalities, including 24 cases of sex chromosome abnormalities, 21 cases of autosomal abnormalities and 10 cases of chromosomal polymorphisms . Among them, the rate of chromosomal aberration in azoospermia group was 25.61% (21/81), that of severe oligospermia was 11.90% (15/126), that of oligospermic sperm disorder was 12.84% (19/148). Conclusion The abnormal rate of karyotype in male infertility patients is 15.45%, much higher than that in normal population. Cytogenetics Chromosome examination of male infertility guidance of fertility is important. Azoospermia in patients with chromosomal examination is particularly necessary.