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目的观察口服孟鲁司特钠治疗咳嗽变异性哮喘的效果。方法 86例咳嗽变异性哮喘患儿行诊断性治疗后,随机分为治疗组46例,口服孟鲁司特钠;对照组40例,吸入丙酸氟替卡松,共6个月,观察用药期间咳嗽缓解情况。疗程结束,随访6个月,观察复发情况。统计有效率、有效患儿症状开始至治疗开始时间(治疗前有症状日)、随访6个月的复发率。结果治疗组46例,有效40例,有效率86.9%,无效6例(加吸入糖皮质激素治疗后4例咳嗽缓解);对照组40例,有效35例,有效率87.5%,无效5例(加孟鲁司特钠治疗后咳嗽缓解);疗程结束,随访6个月,治疗组及对照组均有4例复发。有效率和复发率两组比较差异无统计学意义(P>0.05)。治疗有效患儿治疗前病程明显短于无效患儿(P<0.05)。结论口服孟鲁司特钠与吸入丙酸氟替卡松治疗咳嗽变异性哮喘疗效相当,且疗效与患儿病程长短有关,前者使用更方便。少部分需联合用药,可能与CVA部分患儿在其慢性咳嗽的发病机理中与多种因素参与有关。
Objective To observe the effect of oral montelukast sodium on cough variant asthma. Methods Eighty-six children with cough variant asthma were randomly divided into treatment group (46 cases) and montelukast sodium group (40 cases). Fluticasone propionate was inhaled for 6 months to observe cough relief Happening. End of treatment, followed up for 6 months to observe the recurrence. Statistical efficiency, effective children onset of symptoms until the start of treatment (symptoms before treatment), followed up for 6 months the recurrence rate. Results In the treatment group, 46 cases were effective, 40 cases were effective, 86.9% effective and 6 cases ineffective (cough relief was relieved in 4 cases with inhaled glucocorticoid treatment); in the control group, 40 cases were effective, 35 cases were effective, 87.5% efficient and 5 cases ineffective Cough Luertete sodium treatment of cough relief); end of treatment, follow-up of 6 months, the treatment group and the control group, 4 patients relapsed. Efficacy and relapse rate between the two groups showed no significant difference (P> 0.05). The effective course of treatment in children with effective treatment was significantly shorter than that in ineffective children (P <0.05). Conclusion The efficacy of oral montelukast sodium and fluticasone propionate in the treatment of cough variant asthma is similar, and the curative effect is related to the duration of the disease in children. The former is more convenient to use. A small amount of combination therapy may be related to the involvement of multiple factors in the pathogenesis of chronic cough in some children with CVA.