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本实验目的在于探讨急性低氧和间断低氧适应对局部血流分布的影响。我们将26只家兔分为急性低氧,低氧适应和常氧对照三组。在麻醉状态下用放射性标记的蟾蜍红细胞分别测定左心室、双侧肾、双侧肾上腺的血流量;并分区测定了大脑皮质、海马、丘脑下部、脑干的局部脑血流。吸入10％低氧混合气1小时后,急性低氧组脑局部、左心室、肾上腺的血流显著高于对照。经2周间断低氧适应后,低氧适应组脑局部(脑干除外)、左心室、肾上腺的血流下降。两组动物低氧时的肾血流变化不明显。结果提示,2周间断低氧适应能改变局部血流分布,血流的再分布有利于改善机体的抗低氧能力。
The purpose of this experiment is to investigate the effects of acute hypoxia and intermittent hypoxia on the distribution of local blood flow. We divided 26 rabbits into three groups: acute hypoxia, hypoxia adaptation and normoxic control. The left ventricle, bilateral kidneys and bilateral adrenal blood flow were measured by radiolabeled toad red blood cells under anesthesia. The regional cerebral blood flow of the cerebral cortex, hippocampus, hypothalamus and brainstem was determined. After inhaling 10% hypoxia for 1 hour, the blood flow in brain, left ventricle and adrenal of acute hypoxia group was significantly higher than that of control. After 2 weeks intermittent hypoxia adaptation, hypoxia adaptation group brain (except brain stem), left ventricular, adrenal blood flow decreased. There was no obvious change of renal blood flow in both groups when hypoxia occurred. The results suggest that intermittent hypoxia adaptation at 2 weeks can change the distribution of local blood flow, blood redistribution is conducive to improving the body’s anti-hypoxia capacity.