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对异位妊娠(EP)应用氨甲喋呤(MTX)和PGE_2的衍生物前列磺酮(Sulprostone)治疗作前瞻性随机比较。对21例未破裂的输卵管妊娠病人随机给予两种治疗方案。12例应用MTX 1mg/kg,第1天行异位妊娠囊内注射,第3、5、7天行肌肉注射(IM)。 9例应用前列磺酮500μg,第1天注入妊娠异位囊内,第2、3天IM。监测血清hCG,雌二醇(E_2)和孕酮(P),不能检出hCG水平时为治疗成功(敏感度10mIU/ml)。每周监测2次血象及肝、肾功能。两组病人年龄,孕、产次,受孕、不孕史,诱发排卵和避孕失败等无明显差异。前组8例,后组6例EPs完全消退。
A prospective randomized comparison of methotrexate (MTX) and Sulprostone, a derivative of PGE 2, for ectopic pregnancy (EP). Twenty-one patients with unruptured tubal pregnancy were randomized to two treatment regimens. 12 cases of MTX 1mg / kg, the first day of ectopic pregnancy intracapsular injection, line 3,5,7 days intramuscular injection (IM). Nine cases before application of sulfasalone 500μg, the first day of pregnancy into ectopic cysts, the first 2,3 days of IM. Serum hCG, estradiol (E2), and progesterone (P) were monitored for successful treatment (sensitivity 10 mIU / ml) when hCG levels were not detectable. 2 times a week to monitor blood and liver, kidney function. Two groups of patients age, pregnancy, parity, pregnancy, history of infertility, induced ovulation and contraceptive failure no significant difference. 8 cases in the former group and 6 cases in the latter group completely subsided.