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目的探讨紫杉醇、顺铂、甲酰四氢叶酸钙+5-氟尿嘧啶(TPLF)与表阿霉素、顺铂、甲酰四氢叶酸钙+5-氟尿嘧啶(PELF)化疗方案治疗晚期胃癌的临床疗效。方法53例晚期胃癌患者随机分成两组A组24例和B组29例,A组采用TPLF化疗方案;B组采用PELF化疗方案。两组均治疗2个化疗周期以上。结果两组有效率分别为79.2%(19/24)、75.9%(22/29),组间比较,差异无统计学意义(P>0.05);A组肌肉酸痛明显高于B组(P<0.05),B组消化道反应明显高于A组(P<0.05)。结论TPLF和PELF方案均为治疗晚期胃癌较好的方案,PELF方案可能对经济困难者更适用。
Objective To investigate the clinical effects of paclitaxel, cisplatin, calcium folinate and fluorouracil (TPLF) combined with epirubicin, cisplatin, calcium leucovorin and 5-fluorouracil (PELF) chemotherapy for advanced gastric cancer . Methods Totally 53 patients with advanced gastric cancer were randomly divided into two groups: group A (24 cases) and group B (29 cases). Group A received TPLF chemotherapy and group B received PELF chemotherapy. Both groups were treated for more than 2 cycles of chemotherapy. Results The effective rates of the two groups were 79.2% (19/24) and 75.9% (22/29), respectively. There was no significant difference between the two groups (P> 0.05). The muscle aches in group A were significantly higher than those in group B (P < 0.05). The digestive tract response in group B was significantly higher than that in group A (P <0.05). Conclusion Both TPLF and PELF regimens are better for the treatment of advanced gastric cancer. The PELF regimen may be more suitable for those with financial difficulties.