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目的探讨结直肠癌组织中Pinl与β-catenin的表达及其临床意义。方法应用免疫组化技术检测45例结直肠癌组织中Pinl、β-catenin蛋白的表达,分析其相关性及其与结直肠癌临床病理学特征的关系,并探讨其预后价值。结果Pinl在37.8%(17/45)结直肠癌组织中过表达,β-catenin在64.4%(29/45)结直肠癌组织中异常蓄积,17例Pinl过表达中15例同时存在β-catenin异常蓄积,两者显著正相关(r=0.387,P=0.006);Pinl过表达与结直肠癌病理分级明显相关(P<0.05),与临床分期、淋巴结转移有相关趋势,与浸润深度无明显相关;β-catenin异常蓄积与浸润深度有相关趋势,与病理分级、临床分期及淋巴结转移均无明显相关;Pinl过表达与预后有显著相关性(P<0.01),β-catenin与预后不相关(P=0.099)。结论Pinl在结直肠癌组织中存在过表达,且与β-catenin异常蓄积正相关;Pinl与结直肠癌的预后密切相关。
Objective To investigate the expression of Pin1 and β-catenin in colorectal cancer and its clinical significance. Methods The expression of Pinl and β-catenin protein in 45 cases of colorectal cancer tissues was detected by immunohistochemistry. The correlation between them and the clinicopathological features of colorectal cancer were analyzed. The prognostic value was also discussed. Results Pinl was overexpressed in 37.8% (17/45) of colorectal cancer tissues, with abnormal accumulation of β-catenin in 64.4% (29/45) of colorectal cancers. In the 17 cases of pinl overexpression, 15 cases had β-catenin (R = 0.387, P = 0.006). Pinl overexpression was significantly associated with pathological grade of colorectal cancer (P <0.05), and there was a trend of correlation with clinical stage and lymph node metastasis, but no significant difference with depth of invasion (P <0.01). There was no correlation between the expression ofβ-catenin and the prognosis of gastric cancer (P <0.01). The correlation between the abnormal accumulation ofβ-catenin and the depth of invasion was not related to the pathological grade, clinical stage and lymph node metastasis. (P = 0.099). Conclusion Pinl is overexpressed in colorectal cancer tissues and positively correlated with abnormal accumulation of β-catenin. Pinl is closely related to the prognosis of colorectal cancer.