论文部分内容阅读
目的:探讨IIb/IIIa受体拮抗剂在急性心肌梗死中的应用。方法:在手术过程中给予观察组10μg/kg剂量的IIb/IIIa受体拮抗剂-盐酸替罗非班注射液,同时给予对照组普通肝素。结果:术后,研究组各级TIMI血流与对照组相比,差异具有统计学意义(P<0.05);治疗结束后六个月随访中,研究组出现了1(4.2%)例心绞痛,与对照组共出现的2(8.3%)例心绞痛,3(12.5%)例心力衰竭,2(8.3%)例梗死相关血管再狭窄,2(8.3%)例非梗死血管再狭窄相比,差异具有统计学意义(P<0.05)。结论:IIb/IIIa受体拮抗剂在急性心肌梗死中的应用疗效显著,并发症少,值得临床推荐应用。
Objective: To investigate the use of IIb / IIIa receptor antagonists in acute myocardial infarction. Methods: The rabbits in the observation group were treated with 10μg / kg IIb / IIIa receptor antagonist - tirofiban injection during the operation, while the control group received unfractionated heparin. Results: After operation, the TIMI blood flow at all levels in the study group was significantly lower than that in the control group (P <0.05). During the follow-up six months after the end of treatment, 1 (4.2%) angina pectoris occurred in the study group, Compared with 2 (8.3%) cases of angina pectoris, 3 (12.5%) cases of heart failure, 2 (8.3%) cases of infarct-related vascular restenosis and 2 (8.3%) cases of non-infarcted vascular restenosis, Statistically significant (P <0.05). Conclusion: The application of IIb / IIIa receptor antagonist in acute myocardial infarction has obvious curative effect and few complications, so it is worth recommending for clinical application.