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萘普生(Naproxen Sodium)引起单纯性肺嗜酸粒细胞浸润症(SPIE)至今国内尚未见报道。我们应用广州侨光制药厂生产的萘普生片(批号910301)治疗类风湿关节炎,发生1例SPIE,报告如下。病例报告患者女性,68岁。因双手多掌指关节反复肿痛伴晨僵2年,于1992年2月12日入院。查体:双手多掌指关节肿胀、压痛、活动障碍。实验室检查:血沉62mm/h,类风湿因子阳性,IgG、IgM增高。X线检查受累关节符合类风湿关节炎改变。临床诊断:类风湿关节炎。单纯给予萘普生500mg,每日2次口服。用药3周后,患者关节肿痛明显减轻,但出现干
Naproxen Sodium Caused Simple Pulmonary Eosinophilic Infiltration (SPIE) so far has not been reported in China. We use the Guangzhou Overseas Chinese pharmaceutical production Naproxen tablets (lot number 910301) treatment of rheumatoid arthritis, a case of SPIE, the report is as follows. Case report Patient female, 68 years old. Repeated swelling and pain due to two hands and more metacarpophalangeal joint with morning stiffness 2 years, on February 12, 1992 admission. Physical examination: hands and more palm fingers swelling, tenderness, movement disorders. Laboratory tests: ESR 62mm / h, rheumatoid factor positive, IgG, IgM increased. X-ray examination of affected joints in line with rheumatoid arthritis changes. Clinical diagnosis: rheumatoid arthritis. Naproxen 500 mg given orally twice daily. 3 weeks after treatment, patients with joint pain significantly reduced, but appeared dry