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观察30例新生一周豚鼠腹腔给予胆红素100μg／g（T1组）、200μg／g（T2组）后4hr（Ta组）与8hr（Tb组）时刻神经行为、血清胆红素、脑组织胆红素、脑组织ATP、脑组织形态结构。结果显示：T1组与T2组在给药后4hr血清胆红素均达峰值，并显示脑组织胆红素沉积与ATP含量下降；T2组在给药后8hr有明显神经行为变化，并显示脑组织超微结构改变。表明新生一周豚鼠腹腔给予胆红素100－200μg／g可经体液吸收进入血液循环，并通过血脑屏障沉积于脑组织，致胆红素中毒性脑病发生。
The neurological behavior, serum bilirubin, brain tissue gallbladder at 4h (Ta group) and 8hr (Tb group) were observed in 30 newborn guinea pigs intraperitoneally administered 100μg / g bilirubin (group T1), 200μg / g Hormone, brain tissue ATP, brain tissue morphology The results showed that serum bilirubin peaked at 4 hours after administration in both T1 and T2 groups and showed a decrease in bilirubin deposition and ATP content in brain tissue. T2 group showed obvious neurobehavioral changes at 8 hr after administration and showed that brain Tissue ultrastructural changes. That neonatal week guinea pig intraperitoneal administration of 100-200μg / g bilirubin can be absorbed through the body fluid into the blood circulation, and deposited in the brain tissue through the blood-brain barrier, resulting in bilirubin toxic encephalopathy.