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目的 观察新生儿缺氧缺血性脑病 (HIE)血糖 ,血皮质醇水平变化 ,为临床治疗 HIE提供参考依据。方法 :对 10 0例 HIE患儿测定血糖、血皮质醇水平 ,并以30例正常新生儿作为对照。结果 :10 0例 HIE患儿中 ,中、重度组血糖水平均高于对照组 (P <0 .0 1) ,但轻度组血糖水平与对照组无显著差异 (P >0 .0 5 )。不论轻、中 ,重度组血皮质醇水平均高于对照组 (P <0 .0 0 1) ,且临床分度愈重 ,皮质醇水平愈高(P <0 .0 0 1)。结论 :在处理 HIE患儿时应严密监测血糖 ,应用糖皮质激素应严格掌握适应症和剂量
Objective To observe the changes of blood glucose and blood cortisol levels in neonates with hypoxic-ischemic encephalopathy (HIE) and provide a reference for the clinical treatment of HIE. Methods: Blood glucose and blood cortisol levels were measured in 100 children with HIE and 30 normal newborns were used as controls. Results: The blood glucose level of the moderate, severe and severe group was higher than that of the control group (P <0.01), but there was no significant difference between the mild group and the control group (P> 0.05) . The levels of plasma cortisol were higher in the mild, moderate and severe groups than those in the control group (P0.01). The more severe the clinical grade was, the higher the cortisol level was (P0.01). Conclusion: HIE should be closely monitored in children with treatment of blood glucose, glucocorticoid should be strictly applied indications and doses