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抗dsDNA对SLE是高度特异的,抗ssDNA对SLE不是特异的。SLE的某些抗DNA抗体可以识别由DNA或RNA与一种或多种蛋白相互作用而产生的复合物抗原决定簇,抗体中特异性氨基酸的变化能增强对DNA的结合,具有重复决定簇的复合颗粒是SLE自身抗体产生的可能来源。
Anti-dsDNA is highly specific for SLE and anti-ssDNA is not specific for SLE. Certain anti-DNA antibodies to SLE recognize complex antigenic determinants produced by the interaction of DNA or RNA with one or more proteins, and changes in specific amino acids in the antibody enhance DNA binding with repetitive determinant Composite particles are possible sources of SLE autoantibodies.