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目的:分析河北省香河县人民医院药物不良反应(ADR)发生的特点及引发ADR的相关因素,为临床合理用药提供参考。方法:采用回顾性研究方法,利用医院ADR监测系统,对2008年-2010年收集的284例ADR报告表分别从患者性别、年龄与给药途径、ADR出现时间、涉及药品种类、涉及器官/系统及临床表现等方面进行统计分析。结果:ADR的发生率女性比男性高;中老年组比其他年龄组高;静脉给药较其他给药途径更易发生ADR(72.54%);抗感染药物引发的ADR居首位(52.46%),其次是中药制剂(19.72%);ADR的临床表现以皮肤及附件损害最为常见(49.65%),其次是消化系统反应(26.06%)。结论:应重视临床ADR监测,必要时根据药敏试验结果合理使用抗菌药物。
Objective: To analyze the characteristics of ADR and the related factors of ADR in Xianghe People’s Hospital of Hebei Province, and provide reference for clinical rational drug use. Methods: A retrospective study was conducted to analyze 284 ADR cases collected from 2008 to 2010 from the patient’s sex, age, route of administration and time to ADR using the hospital ADR monitoring system. The ADR monitoring system involved the types of drugs involved in the organ / system And clinical manifestations and other aspects of statistical analysis. Results: The incidence of ADR was higher in females than in males; middle-aged and elderly groups were higher than other age groups; intravenous administration was more likely to occur ADR (72.54%) than other routes of administration; anti-infectives lead ADR (52.46%), Followed by traditional Chinese medicine preparation (19.72%). The clinical manifestations of ADR were the most common lesions (49.65%), followed by the digestive system reaction (26.06%). Conclusion: Clinical ADR monitoring should be emphasized, if necessary, the rational use of antimicrobial agents based on the results of susceptibility testing.