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目前已发现牵张成骨中有多条信号通路参与,如TGF-β、Wnt/β-catenin、整合素、FGF、HIF-1α信号通路等。这些信号通路相互联系、相互影响,组成了一个精确的调控网络,共同参与牵张成骨的调节。然而,由于相关基础研究较少,其具体作用机制仍无法阐明。对牵张成骨相关信号通路的进一步深入研究,将有利于彻底阐明牵张成骨的完整分子机制,从而为临床有效缩短牵张时间、增加成骨稳固性提供理论依据。本文将就在牵张成骨过程中起关键调节作用的相关信号通路及因子的作用机制及研究进展作一综述。
It has been found that there are many signal pathways involved in distraction osteogenesis, such as TGF-β, Wnt / β-catenin, integrin, FGF, HIF-1α signaling pathway. These signaling pathways are interrelated and influence each other, forming a precise regulatory network that participates in the regulation of distraction osteogenesis. However, due to the lack of related basic research, its specific mechanism of action can not be elucidated. The further study of distraction-related signaling pathways will be helpful to completely elucidate the complete molecular mechanism of distraction osteogenesis, which will provide a theoretical basis for effectively shortening the stretch time and increasing the osteogenesis stability. This review summarizes the mechanism and research progress of relevant signaling pathways and factors that play key roles in distraction osteogenesis.