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将动、静脉阻断法用于恒速灌流的在体山羊左肺,使其总压力降区分为动脉端、静脉端及中间段三部分。大肠杆菌内毒素主要升高肺静脉端压力降及肺毛细血管压;山莨菪碱可显著缓解内毒素所致的改变,但对正常肺血管各段压力降无明显影响。5-羟色胺主要升高肺动脉端压力降,对肺静脉端及毛细血管压无明显影响。去甲肾上腺素及组胺主要升高肺静脉端压力降及肺毛细血管压,但对肺动脉端无明显影响。去甲肾上腺素和组胺可能介导内毒素性肺动脉高压。
The arterial and venous occlusion method for constant speed perfusion in vivo goats left lung, so that the total pressure drop is divided into arterial end, venous end and the middle of three parts. Escherichia coli endotoxin mainly increased pulmonary venous pressure and pulmonary capillary pressure; Anisodamine can significantly alleviate the endotoxin-induced changes, but no significant effect on the normal pulmonary vascular pressure drop. Serotonin mainly increased pulmonary artery pressure drop, pulmonary vein side and capillary pressure had no significant effect. Norepinephrine and histamine increased pulmonary venous pressure and pulmonary capillary pressure, but no significant effect on the pulmonary artery. Norepinephrine and histamine may mediate endotoxin-induced pulmonary hypertension.