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目的探讨血清CRP与胰岛素抵抗之间的相关性及其临床意义。方法Ⅱ型糖尿病患者122例,测定其血清超敏CRP、空腹血糖(FPG)、空腹胰岛素(FINS)、甘油三酯(TG)、胆固醇(TCH)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)、尿酸(UA)、糖化血红蛋白(HbA1c)等生化指标。并测定每个病人的血压(收缩压SBP,舒张压DBP),体重指数(BMI)。计算胰岛素抵抗(IR)和胰岛素敏感指数(ISI)。结果高CRP组SBP、DBP、TG、BMI均显著高于正常CRP组(P<0.05),而高CRP组的HDL-C则显著低于正常CRP组(P<0.01)。血清超敏C-反应蛋白与各项指标之间的相关性分析表明,糖尿病病人血清hs-CRP与DBP、BMI、FPG、FINS、TG、UAI、R均存在显著正相关(P<0.05或P<0.01),hs-CRP与HDL-CI、SI之间则存在显著负相关(P<0.05)。结论糖尿病病人血清超敏CRP与胰岛素抵抗之间存在较好的相关性,CRP在糖尿病发生及发展中起一定的作用,超敏CRP可作为Ⅱ型糖尿病的一个早期协助诊断指标。
Objective To investigate the correlation between serum CRP and insulin resistance and its clinical significance. Methods One hundred and twenty-two patients with type II diabetes mellitus (T2DM) were enrolled in this study. Their serum levels of CRP, FPG, FINS, TG, TCH, HDL-C and LDL-C, UA, HbA1c and other biochemical markers. Blood pressure (systolic SBP, diastolic DBP) and body mass index (BMI) were measured in each patient. Insulin resistance (IR) and insulin sensitivity index (ISI) were calculated. Results The SBP, DBP, TG and BMI in high CRP group were significantly higher than those in normal CRP group (P <0.05), while HDL-C in high CRP group was significantly lower than that in normal CRP group (P <0.01). Serum hs-CRP was positively correlated with DBP, BMI, FPG, FINS, TG, UAI and R (P <0.05 or P <0.01). There was a significant negative correlation between hs-CRP and HDL-CI and SI (P <0.05). Conclusions There is a good correlation between serum CRP and insulin resistance in diabetic patients. CRP plays a role in the development and progression of diabetes. Hypersensitive CRP can be used as an early diagnostic indicator of type.