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目的:研究O型孕妇血清中抗A(B)IgG效价与新生儿溶血病(HDN)的关系。方法:对318例夫妇血型不合的O型孕妇血清为研究血样,采用间接抗球蛋白实验(IAT)测定孕妇血清抗A(B)IgG的效价,采用溶血三项试验确定HDN。结果:检出IgG抗体效价<1∶64共254例,占79.9%;≥1∶64的共64例,占20.1%;64例IgG抗A(B)效价≥1∶64的异常孕妇血清样品中,低值组HDN发生率为8.8%,中值组为47.8%,高值组为85.7%,随着效价水平的升高,ABO溶血的发生率也显著升高,高、中、低3组HDN发生率差异有统计学意义(P<0.05)。结论:抗A(B)IgG效价高低与溶血率成正比,抗A(B)IgG效价越高,HDN的发病率越高。
Objective: To study the relationship between anti-A (B) IgG titer and neonatal hemolytic disease (HDN) in serum of O-pregnant women. Methods: Serum samples of 318 pregnant women with O-type incompatible with blood type were used as blood samples. Serum anti-A (B) IgG titer of pregnant women was measured by indirect antiglobulin test (IAT). HDN was determined by hemolytic three tests. Results: Totally 254 cases (79.9%) were detected titers <1:64 of IgG antibody, 64 cases (≥1.164) accounted for 20.1%, and 64 cases of IgG anti-A (B) titers≥1:64 In serum samples, the incidence of HDN was 8.8% in the low-value group, 47.8% in the middle-value group and 85.7% in the high-value group. The incidence of ABO hemolysis was also significantly increased with the increase of the titer level. , The incidence of HDN in the low 3 groups was statistically significant (P <0.05). Conclusion: The anti-A (B) IgG titer is proportional to the hemolysis rate. The higher the anti-A (B) IgG titer, the higher the incidence of HDN.