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的 :探讨小剂量善宁治疗肝硬化门脉高压食管静脉曲张破裂出血的疗效并与常规量进行比较。方法 :6 3例病人随机分为二组。A组 (小剂量善宁组 ) :善宁 0 .1mgiv后 ,以 12 .5 μg/hivdrip维持 72小时 ;B组 (常规量善宁组 ) :善宁 0 .1mgiv后 ,以 2 5 μg/hivdrip维持 72小时。分别观察 2 4小时、2 4～ 72小时内出血停止情况及出血停止 1周内再出血情况 ,并记录副作用。结果 :A、B两组 2 4小时内止血率分别为 5 9.3 %和 6 4.5 % ;2 4～ 72小时内止血率分别为84.4%和 87.1% ;出血停止后 1周内再出血率分别为 3 .12 %和 3 .2 2 %。两组均未出现明显副作用。两组在显效率 ,有效率和 1周内再出血率方面疗效相当 ,无统计学差异 (P >0 .0 5 )。结论 :小剂量善宁方案以其高效、经济、副作用更少可作为该类出血首选的治疗措施
: To investigate the effect of low-dose Shaning on the treatment of hepatic cirrhosis with portal hypertension and esophageal variceal bleeding and compared with the conventional amount. Methods: Sixty-three patients were randomly divided into two groups. Group A (low-dose Shanning group): Shannon 0.1mgiv, with 12.5 μg / hivdrip for 72 hours; B group (conventional amount of Ning group): Shannon 0.1mgiv, 25μg / hivdrip for 72 hours. Respectively observed 24 hours, 24 to 72 hours to stop bleeding and stop bleeding within 1 week of rebleeding, and record the side effects. Results: The hemostatic rates in groups A and B within two and four hours were 53.3% and 65.5% respectively. The rates of hemostasis in 24 and 72 hours were 84.4% and 87.1% respectively. The rates of hemorrhage within one week after hemorrhage stopped were 3.12% and 3.2.2%. No obvious side effects occurred in both groups. The two groups in the markedly effective, effective and within 1 week of rebleeding rate was equivalent, no significant difference (P> 0.05). Conclusion: The low-dose Shannon regimen is the first choice of treatment for such bleeding because of its high efficiency, less cost and fewer side effects