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目的探讨短暂性脑缺血发作(TIA)患者血小板活性的变化情况及临床意义。方法采用流式细胞仪对30例TIA患者外周血的α-2颗粒膜蛋白(CD62P)和溶酶体膜蛋白(CD63)的阳性表达率进行了检测,并与对照组进行结果比较。结果 TIA组发作期和缓解期的CD62P的阳性表达率分别为(8.22±1.04)和(7.96±0.91),CD63的阳性表达率分别为(8.04±1.08)和(8.01±1.22);对照组的CD62P和CD63的阳性表达率分别为(2.01±0.43)和(0.88±0.26)。经统计学处理,TIA患者在发作期和缓解期的CD62P、CD63阳性表达率均高于正常对照组,差异均具有统计学意义(P<0.01)。结论 TIA患者在发作期和缓解期的血小板表面CD62P和CD63表达均增强,表明TIA患者的血小板活化程度异常增高,为临床进行抗血小板治疗提供了实验依据。
Objective To investigate the changes of platelet activity in patients with transient ischemic attack (TIA) and its clinical significance. Methods The positive expression rate of α-2 granule membrane protein (CD62P) and lysosomal membrane protein (CD63) in peripheral blood of 30 TIA patients was detected by flow cytometry, and compared with the control group. Results The positive rates of CD62P expression in the TIA group were (8.22 ± 1.04) and (7.96 ± 0.91), respectively. The positive rates of CD63 expression in the TIA group were (8.04 ± 1.08) and (8.01 ± 1.22) The positive rates of CD62P and CD63 were (2.01 ± 0.43) and (0.88 ± 0.26), respectively. Statistically, the positive rates of CD62P and CD63 in patients with TIA were significantly higher than those in normal controls (P <0.01). Conclusions The expression of CD62P and CD63 on platelet surface in patients with TIA increased during the attack and remission stages, indicating abnormally increased platelet activation in patients with TIA, providing an experimental basis for clinical antiplatelet therapy.