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小儿急性淋巴母细胞白血病(ALL),近十余年来预后显著改善,5年生存率达50%,但也有对目前的治疗方案难以显效者。因而许多学者把治疗反应性、临床及检查所见上的特征作为判定预后好坏的因子。Robinson等报告了936例未经治疗的ALL患儿,按六种不同的中枢神经白血病(CNS—L)预防法,无选择地接受其中之一进行治疗。并对患儿的初发症状、治疗前的白细胞数、血小板数、血红素含量、年龄及脏器肿大、纵隔肿瘤、有无并发CNS—L、性别及人
In children with acute lymphoblastic leukemia (ALL), the prognosis has improved significantly over the past decade and the 5-year survival rate has reached 50%. However, there are also some patients who are refractory to the current treatment plan. Therefore, many scholars regard the characteristics of therapeutic reactivity, clinical findings and examinations as the factors that determine the prognosis. Robinson et al. Reported 936 untreated ALL children who were treated selectively with one of six different CNS-L prophylaxis methods. And the initial symptoms of children, the number of white blood cells before treatment, platelet count, heme level, age and organ enlargement, mediastinal tumor, with or without CNS-L, gender and human