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目的探讨人巨细胞病毒(HCMV)激活感染与肿瘤坏死因子α(TNF-α)水平和颈动脉粥样硬化斑块性质的关系。方法采用免疫荧光法检测外周血白细胞HCMV-PP65抗原,以其作为HCMV激活感染的指标,对212例颈动脉粥样硬化患者分别进行HCMV-PP65抗原、TNF-α水平检测和颈动脉超声检查。结果 HCMV-PP65抗原阳性组TNF-α含量为(3.04±0.37)μg/L与HCMV-PP65抗原阴性组(1.37±0.17)μg/L比较,差异有统计学意义(P<0.01);HCMV-PP65抗原阳性组存在不稳定性斑块的患者44例(69.84%),HCMV-PP65抗原阴性组存在不稳定性斑块的患者72例(48.32%),两组比较差异有统计学意义(χ2=8.82,P<0.01)。结论 HCMV激活感染可引起TNF-α水平增高,可能与颈动脉粥样硬化斑块不稳定性有关。
Objective To investigate the relationship between human cytomegalovirus (HCMV) activated infection and tumor necrosis factor-α (TNF-α) and carotid atherosclerosis plaque. Methods HCMV-PP65 antigen was detected by immunofluorescence method. HCMV-PP65 antigen was detected by immunofluorescence. HCMV-PP65 antigen, TNF-α level and carotid artery ultrasonography were detected in 212 patients with carotid atherosclerosis. Results The level of TNF-αin HCMV-PP65 positive group was (3.04 ± 0.37) μg / L and HCMV-PP65 negative group was (1.37 ± 0.17) μg / L, There were 44 patients (69.84%) with unstable plaques in PP65 antigen positive group, 72 patients (48.32%) with unstable plaque in negative HCMV-PP65 antigen group, the difference was statistically significant (χ2 = 8.82, P <0.01). Conclusion HCMV infection can cause an increase of TNF-α level, which may be related to the instability of carotid atherosclerosis plaque.