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氟脲嘧啶(5-Fu)所致急性再障较少见,我院遇到一例,报告如下;患者谢×,女性,28岁,因停经50天,下腹疼痛20天,阴道不规则流血2天住某院诊断为葡萄胎,于1989年9月26日用5-Fu治疗,1000mg/d静滴,共用七天。化疗前血象均在正常范围,化疗结束后即感头昏,乏力,心慌,发热,阴道不规则流血。白细胞1.25×10~9/L,血红蛋白60g/L,血小板10×10~9/L,曾用止血药,输血等治疗,病情无好转,于1989年10月14日入我院。 检体:T38.4℃,神清合作,重度贫血貌,全身皮肤散在出血点,浅表淋巴结未扪门,胸骨无压痛,心肺无异常,肝脾未扪及,神经系统反射无异常发现。
Fluorouracil (5-Fu) caused by acute aplastic anemia is rare, our hospital encountered a case, the report is as follows; patients Xie ×, female, 28 years old, due to menopause 50 days, abdominal pain for 20 days, vaginal irregular bleeding 2 Day to live in a hospital diagnosed as hydatidiform mole, on September 26, 1989 with 5-Fu treatment, intravenous infusion of 1000mg / d, sharing seven days. Chemotherapy before the blood are in the normal range, after chemotherapy that dizziness, fatigue, palpitation, fever, vaginal irregular bloodshed. White blood cells 1.25 × 10 ~ 9 / L, hemoglobin 60g / L, platelets 10 × 10 ~ 9 / L, hemostatic drugs, transfusion and other treatment, the condition did not improve, in October 14, 1989 into our hospital. Samples: T38.4 ℃, Shen Qing cooperation, severe anemia appearance, systemic skin scattered in the bleeding point, superficial lymph node without palpable door, sternum without tenderness, no abnormal heart and lung, liver and spleen not palpable, nervous system reflex found no abnormalities.