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一、实验结果表明,5号丸,6号丸以及S.J.209缓解片以20毫克/公斤体重/日剂量给家犬连续服用3天后,都未出现呕吐、腹泻等消化道反应,也未发现有整个的丸子被排出,食欲和精神反应都很正常。S.J.209缓解片增至25毫克/公斤体重/日剂量及30毫克/公斤体重/日剂量,边续服用了三天亦未出现呕吐及排出整片等异常情况。二、以酒石酸锑钾,S.J.66、S.J.59等代替5号丸中的S.J.209,并用相同的方法制成缓解丸。前两者以15毫克/公斤体重/日剂量,后者以20毫克/公斤体重/日剂量给家犬口服,均产生呕吐反应,而酒石酸锑钾缓解丸的反应更为严重。三、本身带有缓解作用的酒石酸锑钾隣苯三酚以硬脂酸、虫胶(或玉蜀黍朊)为缓解剂,再加上淀粉、甘草、阿拉伯胶、甘油等赋形剂制成的丸、片剂不引起家犬的呕吐、腹泻等消化道付反应。我们又以未制成片剂的S.J.209缓解核心,对小白鼠日本血吸虫病进行实验治疗,用相当于S.J.209 3毫克/20克体重/日,15天疗法,虫数减少率达88%,这说明了S.J.209经缓解后仍然有效,同时亦可表明其吸收良好。
First, the experimental results show that 5 pills, 6 pills and SJ209 remission tablets to 20 mg / kg body weight / daily dose to domestic dogs after taking 3 days, did not appear vomiting, diarrhea and other gastrointestinal reactions, but also did not find Entire balls are discharged, appetite and mental reactions are normal. S.J.209 remission tablets increased to 25 mg / kg body weight / daily dose and 30 mg / kg body weight / daily dose, taking three days without taking the vomit and discharge the entire film and other anomalies. Second, antimony potassium tartrate, S.J.66, S.J.59, etc. instead of No. 5 S.J.209 pills, and use the same method of remission pill. The former two were given oral dose of 15 mg / kg body weight / day and the latter oral administration to domestic dogs at a dose of 20 mg / kg body weight / day. The reaction of antimony potassium tartrate relieved pill was more serious. Third, with its own anti-inflammatory potassium tartrate pyrogallol to stearic acid, shellac (or corn gluten) as a reliever, plus starch, licorice, gum arabic, glycerol and other excipients pill , Tablets do not cause dogs vomiting, diarrhea and other gastrointestinal reactions. We have not made tablets SJ209 ease the core of the experimental treatment of mice with Japanese schistosomiasis, with the equivalent of SJ209 3 mg / 20 g body weight / day, 15 days therapy, a reduction rate of 88% of the number of insects, This shows that SJ209 still effective after remission, but also shows that its absorption is good.