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[目的]观察普伐他汀联合非洛地平治疗老年单纯收缩期高血压病的临床效果。[方法]86例老年单纯收缩期高血压患者随机分为观察组和对照组各43例,两组均口服非洛地平缓释片5mg,每日1次;治疗组在此基础上每晚口服普伐他汀20mg,如2周内血压未达标,将非洛地平缓释片剂量调整为10mg/次。两组连续治疗6个月,检查及记录2组血压、脉压差及TC的变化。[结果]2组治疗前各项指标均无统计学差异。治疗后,2组间舒张压无统计学差异,而与对照组比较,治疗组收缩压、脉压差、总胆固醇有显著下降(P﹤0.05)。治疗组未见肌痛、肌炎、ALT升高、肌酸激酶升高等不良反应。[结论]普伐他汀与非洛地平缓释片联合治疗,能有效降低老年单纯收缩期高血压患者的血压及脉压差,安全性良好,值得临床推广应用。
[Objective] To observe the clinical effect of pravastatin combined with felodipine on senile isolated systolic hypertension. [Method] A total of 86 elderly patients with isolated systolic hypertension were randomly divided into observation group (43 cases) and control group (43 cases). Both groups were given 5 mg sustained-release tablets of felodipine once daily. Pravastatin 20mg, such as 2 weeks of blood pressure does not meet the standard, the felodipine sustained-release tablets dose adjusted to 10mg / time. Two groups of continuous treatment for 6 months, check and record the two groups of blood pressure, pulse pressure and TC changes. [Results] There was no significant difference between the two groups before treatment. After treatment, there was no significant difference in diastolic blood pressure between the two groups. Compared with the control group, systolic blood pressure, pulse pressure and total cholesterol in the treatment group decreased significantly (P <0.05). The treatment group showed no muscle pain, myositis, elevated ALT, elevated creatine kinase and other adverse reactions. [Conclusion] The combination therapy of pravastatin and felodipine sustained release tablets can effectively reduce the blood pressure and pulse pressure difference of elderly patients with isolated systolic hypertension, and is safe and worthy of clinical application.