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目的观察急性肺损伤(ALI)新生儿外周血肿瘤坏死因子(TNF-α)变化,探讨TNF-α在新生儿ALI诊断中的意义。方法采用酶联免疫吸附试验定量测定ALⅠ组,普通肺炎组及健康对照组三组90例新生儿血清TNF-α水平,并做比较。结果 ALⅠ组新生儿与普通肺炎组,健康对照组比较,入院24h血清TNF-α水平明显增高,差异有统计学意义(P<0.01)。普通肺炎组与健康对照组比较无统计学差异(P>0.05)。结论 TNF-α在新生儿ALI早期诊断中起一定作用。
Objective To observe the changes of tumor necrosis factor (TNF-α) in peripheral blood of neonates with acute lung injury (ALI) and to explore the significance of TNF-α in the diagnosis of neonatal ALI. Methods Serum levels of TNF-α in 90 newborns of AL Ⅰ group, common pneumonia group and healthy control group were measured by enzyme linked immunosorbent assay (ELISA), and compared. Results Compared with normal pneumonia group and healthy control group, the level of TNF-α in serum of ALI group was significantly higher at 24h after admission (P <0.01). There was no significant difference between ordinary pneumonia group and healthy control group (P> 0.05). Conclusion TNF-α plays an important role in the early diagnosis of neonatal ALI.