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目的:制备利福平栓剂并测定其体外溶出度。方法:以明胶及甘油等为基质制备利福平栓剂;采用紫外分光光度法测定利福平栓剂的溶出度,并与市售利福平胶囊比较。结果:利福平检测浓度在10.0~60.0μg.mL-1范围内线性关系良好(r=0.9999),平均回收率为99.87%(RSD=0.42%,n=6)。利福平栓剂及胶囊45min时体外溶出度分别为(89.9±0.97)%、(79.8±1.14)%。结论:该制剂制备方法简单,成模性好,成本低,体外溶出度较高。
OBJECTIVE: To prepare rifampin suppository and determine its in vitro dissolution. Methods: The preparation of rifampicin suppository with gelatin and glycerol as the matrix. The dissolution of rifampin suppository was determined by UV spectrophotometry and compared with the commercially available rifampin capsule. Results: The calibration curve of rifampin showed a good linearity (r = 0.9999) within the range of 10.0-60.0 μg.mL-1. The average recovery was 99.87% (RSD = 0.42%, n = 6). In vitro dissolution rates of rifampicin suppository and capsule were (89.9 ± 0.97)% and (79.8 ± 1.14)% respectively at 45 min. Conclusion: The preparation method is simple, good mold, low cost, higher dissolution in vitro.