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目的:研究大鼠定量组织速度成像速度曲线特点,探讨该技术在大鼠的应用,为大鼠心血管疾病模型心功能的评价找到更准确、快速、无创的方法。方法:应用传统的超声心动图方法和定量组织速度成像(QTVI)技术检测30只正常大鼠的心脏,测量常用心功能参数,获得心尖四腔切面的QTVI图像,脱机分析后室间隔和左室侧壁二尖瓣环处的速度曲线,记录收缩期峰值速度Vs、舒张早期峰值速度Ve、左房收缩期峰值速度Va,并计算Ve/Va。并将后室间隔和左室侧壁的平均Vs与M型超声获得的左室射血分数(EF)进行相关分析。结果:30只大鼠均能显示胸骨旁左心长轴、大血管短轴、乳头肌短轴及心尖四腔切面,彩色血流显像可检测出二尖瓣口血流情况,所有大鼠二尖瓣口血流频谱均为单峰;室间隔的QTVI速度曲线收缩期多为双峰,左室侧壁的QTVI速度曲线收缩期多为单峰,舒张期部分取样点可见明显的E峰和A峰;后室间隔和左室侧壁的平均Vs与EF呈直线相关(相关系数分别为0.62,P<0.001)。结论:QTVI能够提供大鼠收缩及舒张功能的定量信息,是评价大鼠心血管疾病模型心功能的一个较有前途的方法,可以弥补传统评价方法的不足。
OBJECTIVE: To study the characteristics of quantitative tissue velocity imaging velocity profile in rats, and to explore the application of this technique in rats to find a more accurate, rapid and noninvasive method for the evaluation of cardiac function in rat models of cardiovascular diseases. Methods: The heart of 30 normal rats were detected by traditional echocardiography and quantitative tissue velocity imaging (QTVI) technique. Common cardiac function parameters were measured to obtain QTVI images of apical four-chamber view. The posterior compartment and left Ventricular mitral annulus velocity curve at the systolic peak velocity Vs, peak diastolic velocity Ve, left atrial peak systolic velocity Va, and calculate Ve / Va. The correlation between posterior ventricular septum and left ventricular average Vs and left ventricular ejection fraction (EF) obtained by M-mode ultrasound was analyzed. Results: All the 30 rats showed the left parasternal long axis of the parasternal axis, the short axis of the large blood vessel, the short axis of the papillary muscle and the apex of the atrium. Color flow imaging could detect the mitral flow in the mitral orifice. Mitral valve blood flow spectrum were unimodal; interventricular septum QTVI velocity curve systolic mostly double peaks, left ventricular QTVI velocity curve systolic mostly single peak diastolic part of the sampling point visible E peak And A peak. The mean Vs of posterior septum and left ventricular wall was linearly correlated with EF (correlation coefficient was 0.62, P <0.001). Conclusion: QTVI can provide quantitative information about the systolic and diastolic function of rats. It is a promising method to evaluate the cardiac function of rat model of cardiovascular disease and can make up for the deficiency of traditional evaluation methods.