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In Weste medicine,therapeutic drugs for the treatment of diseases are required to have a well-defined pure molecular target (one protein or one gene) because the understanding of molecular mechanisms for diseases are largely based on the principle of phenotype-genotype relationship,ie,"one gene encoding one protein and responsible for one phenotype"[1].In clinical practice,however,treatment of many diseases often requires a multi-drug regimen that combines several monotherapies targeting on different molecules to optimize pharmacodynamics and/or pharmacokinetics for the purpose of improving therapeutic efficacy and/or reducing toxicity and adverse reactions[2].