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目的:探讨卷曲霉素对治疗耐多药肺结核的临床治疗效果,研究其临床应用效果。方法:选择我院中2015年4月-2015年9月中收治的100例耐多药性肺结核患者,按照其入院顺序分为对照组以及实验组,每组中包含50例耐多药性肺结核患者。实验组患者采用卷曲霉素与左氧氟沙星进行联合用药;对照组采用链霉素联合左氧氟沙星用药。所有患者均进行15个月的化疗疗程,治疗结束后对两组患者的治疗结果以及疗效进行对比。结果:实验组患者在10个月以及15个月时的痰菌转阴率为68%和82%;而对照组患者在10个月以及15个月时的痰菌转阴率为42%和58%,其差异具有统计学意义(P<0.05)。结论:采用卷曲霉素对耐多药结核进行治疗能够提高化学治疗疗效,并且用药后产生的不良反应较小,大多数患者都能够承受其药效,值得在临床上推广使用。
Objective: To investigate the clinical efficacy of capreomycin in the treatment of multidrug-resistant pulmonary tuberculosis and to study its clinical effect. Methods: A total of 100 MDR-TB patients admitted to our hospital from April 2015 to September 2015 were divided into control group and experimental group according to their order of admission. Each group contained 50 patients with multi-drug resistant pulmonary tuberculosis. Patients in the experimental group were treated with capreomycin and levofloxacin, while those in the control group were treated with streptomycin and levofloxacin. All patients were treated with chemotherapy for 15 months. After the treatment, the treatment results and the curative effects were compared between the two groups. Results: In the experimental group, the sputum negative conversion rates were 68% and 82% at 10 months and 15 months respectively. In the control group, sputum negative conversion rates were 42% at 10 months and 15 months 58%, the difference was statistically significant (P <0.05). Conclusion: The use of capreomycin in the treatment of multidrug-resistant tuberculosis can improve the curative effect of chemotherapy, and the side effects produced after treatment are relatively small. Most patients are able to tolerate its efficacy and are worth popularizing in clinic.