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目的探讨前列腺组织中凋亡抑制基因XIAP的表达及其与临床病理特征的关系。方法应用RT-PCR和免疫组化(SP)法,检测XIAP在62例前列腺癌组织中的表达情况。结果62例前列腺癌组织中XIAP基因高表达,正常的前列腺组织中XIAP均无明显表达。62例前列腺癌组织中XIAP蛋白阳性表达共有43例(69．4％),低分化组XIAP蛋白阳性表达率(94．4％)明显高于中分化(70．0％)和高分化组(35．7％),其差异有统计学意义(P<0．05);XIAP蛋白阳性表达与前列腺癌的临床分期比较亦有统计学意义,临床分期愈晚,XIAP蛋白阳性表达率愈高(P<0．05)。结论XIAP与前列腺癌的发生发展有关,检测前列腺癌组织中XIAP表达可能对判断前列腺癌预后有一定意义。
Objective To investigate the expression of apoptosis-suppressing gene XIAP in prostate tissue and its relationship with clinicopathological features. Methods RT-PCR and immunohistochemistry (SP) were used to detect the expression of XIAP in 62 cases of prostate cancer. Results The expression of XIAP gene in 62 cases of prostate cancer was high, while no expression of XIAP in normal prostate tissue was found. The positive expression rate of XIAP in 62 cases of prostate cancer was 43 (69.4%), while the positive rate of XIAP in poorly differentiated group was significantly higher than that of moderately differentiated group (70.0%) and well differentiated group 35.7%), the difference was statistically significant (P <0.05). The positive expression of XIAP protein was also significantly different from the clinical staging of prostate cancer. The later the clinical staging, the higher the positive expression rate of XIAP protein P <0.05). Conclusions XIAP is associated with the occurrence and development of prostate cancer. Detecting the expression of XIAP in prostate cancer may be of significance in judging the prognosis of prostate cancer.