吲哚胺2,3-双加氧酶与白血病的关系研究

• 作 者: 白改改 周芙玲 张王刚
• 机 构: 西安交通大学医学院第二附属医院血液科,
• 出 处: 医学综述
• 发表日期: 2010年10期
• 关键词: 白血病细胞 双加氧酶 吲哚胺 免疫逃逸 色氨酸代谢 1-甲基色氨酸 细胞介导 干扰素γ 免疫反应 信号转导

吲哚胺2,3-双加氧酶(IDO)是一种含铁血红素单体蛋白,其表达和活化可以被干扰素γ强烈诱导。通过催化色氨酸降解,使表达IDO的肿瘤细胞周围形成低色氨酸环境,由于色氨酸是体内必需氨基酸,缺乏色氨酸时蛋白质合成下降,外周T淋巴细胞的增殖受到抑制。目前大量研究表明IDO在白血病细胞中较高表达,抑制T细胞的增生和T细胞介导的免疫反应,使T细胞活化信号转导受阻,诱导白血病细胞发生免疫逃逸。

Indoleamine 2,3-dioxygenase (IDO) is a heme-containing monomeric protein whose expression and activation can be strongly induced by interferon gamma. By catalyzing the tryptophan degradation, the low tryptophan environment is formed around the IDO-expressing tumor cells. Since tryptophan is the essential amino acid in the body, protein synthesis decreases in the absence of tryptophan and the proliferation of peripheral T lymphocytes is inhibited. At present, a large number of studies have shown that IDO is highly expressed in leukemia cells and inhibits T cell proliferation and T cell-mediated immune responses, blocking the activation of T cell activation signal and inducing leukemia cell immune escape.