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目的研究伴EB病毒血症的噬血细胞性淋巴组织细胞增生症患者的实验室检查特征。方法将80例嗜血细胞性淋巴组织细胞增生症患者实验室检查情况进行回顾性分析。结果检查结果可见本组患者血红蛋白浓度、白细胞计数以及血小板计数降低,且随着患者病情越严重,该三项检查结果数值越低。血清铁蛋白、总胆红素、谷丙转氨酶、谷草转氨酶以及乳酸脱氢酶均有所升高。患者普遍存在凝血功能异常现象和在出血倾向。且随着症状加重,凝血功能异常现象越明显。经统计学分析,差异具有显著意义(P<0.01)。患者PCR检测结果为所有患者copy数均升高,数值均大于1.0×103copy/m L。且随着患者病情的加重而上述指标异常情况越明显。经统计学分析,差异具有统计学意义(P<0.01)。结论伴EB病毒血症的噬血细胞性淋巴组织细胞增生症是临床上一种难治疾病,掌握正确实验室诊断方法,能有效指导医生做出正确判断,有利于患者接受有效治疗。
Objective To investigate the laboratory features of patients with hemophagocytic lymphohistiocytosis with EB viremia. Methods A retrospective analysis of 80 cases of hemophilic lymphohistiocytosis in patients with laboratory tests. Results of the test results showed that patients with hemoglobin concentration, white blood cell count and platelet count decreased, and with the more serious the patient’s condition, the lower the value of the three test results. Serum ferritin, total bilirubin, alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase were elevated. The prevalence of coagulation disorders and bleeding tendency in patients. And with the aggravation of symptoms, coagulation abnormalities more obvious. The statistical analysis, the difference was significant (P <0.01). The patient’s PCR test results showed that the copy numbers of all patients were higher than 1.0 × 103copy / m L. And with the aggravation of the patient’s condition, the abnormality of the above index is more obvious. After statistical analysis, the difference was statistically significant (P <0.01). Conclusions Hemophagocytic lymphohistiocytosis with EB viremia is a kind of refractory disease in clinic. To master the correct method of laboratory diagnosis can effectively guide the doctors to make correct judgments and help patients receive effective treatment.