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观察实验性糖尿病大鼠后肢血管的病理形态改变及血栓形成情况，测定血纤溶酶原活化物抑制物（PAI－1）。结果显示：糖尿病（DM）组和胰岛素治疗（INS）组的血管内皮细胞、内弹力膜和平滑肌病变与对照组比较均有显著性差异（P＜0．05）。DM组的PAI－1活性明显升高（P＜0．05），尤其是有血栓形成者更为显著；INS组明显低于DM组（P＜0．05），提示DM的PAI－1活性增高与血栓形成呈正相关。INS治疗可降低PAI－1活性。
Histopathological changes and thrombosis of hind limbs were observed in diabetic rats, and plasminogen activator inhibitor (PAI-1) was measured. The results showed that the vascular endothelial cells, endometrial and smooth muscle lesions in DM group and INS group were significantly different from those in control group (P <0.05). PAI-1 activity in DM group was significantly higher than that in DM group (P <0.05), especially in those with thrombosis; INS group was significantly lower than that in DM group (P <0.05), suggesting that PAI-1 activity in DM Increased and thrombosis was positively correlated. INS treatment reduced PAI-1 activity.