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氨基甙类抗生素中以新霉素耳蜗毒性最大,卡那霉素和链霉素次之。动物试验已证实新霉素中耳局部应用具有耳蜗毒性,临床应用0.5～1％卡那霉素滴耳治疗急、慢性化脓性中耳炎。鉴于对卡那霉素中耳应用的耳蜗毒性研究国內尚未见报道,特进行以下动物实验研究。一、材料和方法: 1.实验动物:健康豚鼠21只,体重250～400克,Preyer’s反射均阳性。实验组:豚鼠16只,分三组:第一组5只,中耳置入5％卡那霉素0.1毫升,15天杀死;第二组7只,中耳置入5％卡那霉素0.1毫升,30天杀死,第三组4只,中耳置入10
Among the aminoglycosides, neomycin was the most toxic, followed by kanamycin and streptomycin. Animal experiments have confirmed neomycin topical application of cochlear toxicity, clinical application of 0.5 ~ 1% kanamycin ear drops treatment of acute and chronic suppurative otitis media. In view of the cochlear toxicity of kanamycin middle ear application has not been reported in the country, the following animal experiments. First, the material and methods: 1. Experimental animals: healthy guinea pigs 21, weighing 250 to 400 grams, Preyer’s reflexes were positive. Experimental group: Guinea pigs 16, divided into three groups: the first group of 5, middle ear put 5% kanamycin 0.1 ml, 15 days to kill; the second group of 7, middle ear into 5% kanamycin 0.1 ml, killed 30 days, the third group of 4, 10 into the middle ear