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关于二甲苯对孕鼠的毒作用情况,各说不一。本文采用吸入染毒法研究了二甲苯对孕鼠的毒作用,将研究结果报告如下: 材料与方法样品与动物:二甲苯为分析纯,系齐鲁石化公司研究院试剂厂产品。敌枯双是本次致畸试验的阳性对照药物;Wistar成年大鼠,中国预防医学科学院动物中心提供。剂量分组:对查到精子的雌鼠随机分为五组,即阴性对照组,敌枯双(6mg/kg)阳性对照组,二甲苯0.5g/m~3、3g/m~3及10g/m~3三个剂量组。染毒方法:敌枯双采用经口染毒,二甲苯各剂量
Xylene on the toxic effects of pregnant rats, vary. In this paper, the toxic effects of xylene on pregnant rats were studied by inhalation and exposure method. The results are reported as follows: Materials and Methods Samples and Animals: Xylene is of analytical grade, which is the product of Reagent Factory of Qilu Petrochemical Company. The enemy drown double is the teratogenic test positive control drug; Wistar adult rat, Chinese Academy of Preventive Medicine Animal Center. Dose grouping: Female sperm were randomly divided into five groups: negative control group, positive control group (6mg / kg), xylene 0.5g / m3-3g / m3 and 10g / m ~ 3 three dose groups. Methods of exposure: enemy withered double use of oral exposure, xylene each dose