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目的:研究氟尿嘧啶泡囊凝胶剂的体外透皮扩散率及皮内滞留率。方法:建立用分光光度法测定氟尿嘧啶的方法,通过离体鼠皮透皮扩散试验,测定氟尿嘧啶泡囊凝胶的透皮扩散率及皮外残留率,并与氟尿嘧啶凝胶剂和医院制剂乳膏等作对照。结果:氟尿嘧啶泡囊凝胶剂的12 h的透皮累积扩散率仅为乳膏的10%,但皮内滞留率却增加2倍以上。结论:氟尿嘧啶泡囊凝胶剂可大大减少透过皮肤进入全身的药量,显著增加局部浓度,利于提高对皮肤病的疗效和降低全身毒性。
Objective: To study the in vitro transdermal diffusivity and intradermal retention of fluorouracil vesicle gels. Methods: The method of determining fluorouracil by spectrophotometry was established. The transdermal diffusivity and residual rate of fluorouracil vesicle gel were determined by the in vitro rat skin transdermal diffusion test. The fluorouracil gel and hospital preparation cream For comparison. RESULTS: Fluorouracil vesicle gels had a 12-h cumulative transdermal diffusivity of only 10% of creams, but the intradermal retention rate increased more than 2-fold. Conclusion: Fluorouracil vesicle gels can greatly reduce the amount of drug that penetrates the skin into the body, significantly increase the local concentration, which will help to improve the curative effect on skin diseases and reduce systemic toxicity.