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目的:探讨14-3-3θ蛋白在鼻咽癌中的表达和临床意义。方法:在72例人鼻咽癌和正常鼻咽组织中利用免疫组织化学染色法检测14-3-3θ蛋白的表达情况,并分析其表达与鼻咽癌临床病理学特征之间的关系。结果:在72例鼻咽癌和正常鼻咽组织中,14-3-3θ蛋白表达的阳性率分别为69.4%和15.2%。统计学分析表明,14-3-3θ蛋白的表达与鼻咽癌临床分级(P=0.045)、淋巴结转移(P<0.001)、肿瘤复发(P=0.041)具有显著相关性,而与鼻咽癌患者的年龄(P=0.444)、性别(P=0.795)、组织类型(P=0.468)等均无关。Spearman相关性统计分析发现,14-3-3θ蛋白高表达与鼻咽癌高临床分级(r=-0.256,P=0.030)、淋巴结转移阳性(r=0.506,P<0.001)、肿瘤复发(r=0.106,P=0.033)呈正相关,而与鼻咽癌患者的年龄、性别、组织类型等均无相关性(P>0.05)。结论:在鼻咽癌组织中,癌基因14-3-3θ在鼻咽癌组织中表达增加,并且与疾病临床分级、转移复发等密切相关。
Objective: To investigate the expression of 14-3-3θ protein in nasopharyngeal carcinoma and its clinical significance. Methods: The expression of 14-3-3θ protein was detected by immunohistochemical staining in 72 cases of human nasopharyngeal carcinoma and normal nasopharyngeal tissues. The relationship between the expression of 14-3-3θ protein and clinicopathological features was analyzed. Results: The positive rates of 14-3-3θ protein expression in 72 NPC and normal nasopharyngeal tissues were 69.4% and 15.2% respectively. Statistical analysis showed that the expression of 14-3-3θ protein was significantly correlated with clinical grade (P = 0.045), lymph node metastasis (P <0.001) and tumor recurrence (P = 0.041), but not with nasopharyngeal carcinoma The patient’s age (P = 0.444), sex (P = 0.795), type of tissue (P = 0.468), etc. have nothing to do. Spearman correlation analysis showed that high expression of 14-3-3θ protein was associated with high clinical grade of nasopharyngeal carcinoma (r = -0.256, P = 0.030), lymph node metastasis (r = 0.506, = 0.106, P = 0.033), but not with the age, sex, histological type of NPC patients (P> 0.05). Conclusion: In nasopharyngeal carcinoma, the expression of oncogene 14-3-3θ in nasopharyngeal carcinoma is increased, which is closely related to the clinical grade, metastasis and recurrence.