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目的探讨乳腺浸润性导管癌及乳腺不典型增生组织中蛋白酪氨酸磷酸酶PRL-3表达情况。方法采用SP法及RT-PCR方法检测60份乳腺癌组织及50份乳腺不典型增生组织标本中PRL-3表达情况,分析PRL-3与乳腺浸润性导管癌临床病理特征的关系。结果在乳腺癌癌变过程中PRL-3表达阳性率呈递增趋势;PRL-3表达与有无淋巴结转移有相关性(P=0.011);PRL-3在乳腺癌中表达明显高于乳腺不典型增生组织(P<0.05)。结论乳腺癌组织中PRL-3在蛋白及基因水平呈高表达,一定程度上提示PRL-3与乳腺癌发生密切相关。
Objective To investigate the expression of protein tyrosine phosphatase (PRL-3) in breast invasive ductal carcinoma and breast dysplasia. Methods The expression of PRL-3 in 60 breast cancer tissues and 50 atypical dysplasia tissues was detected by SP method and RT-PCR. The relationship between PRL-3 and the clinicopathological features of invasive ductal breast cancer was analyzed. Results The positive rate of PRL-3 expression in breast cancer was increasing. The expression of PRL-3 was correlated with lymph node metastasis (P = 0.011). The expression of PRL-3 in breast cancer was significantly higher than that in atypical hyperplasia of breast Tissue (P <0.05). Conclusion PRL-3 in breast cancer tissues is highly expressed at the protein and gene levels, which suggests that PRL-3 is closely related to breast cancer.