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目的通过检测肝癌组织及癌旁组织中survivin及caspase-3的表达,了解二者与肝癌之间的关系及其相互关系,为进一步探讨肝癌的发病机制、早期诊断及寻找科学的治疗方法提供一定的理论依据。方法以免疫组化法染色,观察survivin及caspase-3在肝癌组织及癌旁组织中的表达,并结合患者的临床病理特点进行综合分析。结果survivin在肝癌组织中的表达高于癌旁组织(P<0.01),与年龄、性别、AFP是否阳性无关(P>0.05),有门静脉癌栓者表达较高(P<0.01);caspase-3在癌旁组织中的表达高于肝癌组织(P<0.01);survivin与caspase-3在肝癌组织中的表达强度呈负相关(P<0.05);survivin阳性肝癌患者生存率低于survivin阴性肝癌患者(P<0.05)。结论survivin可抑制细胞凋亡,促进肝癌的发生;caspase-3促进细胞凋亡,抑制肝癌的发生;survivin抑制细胞凋亡与caspase-3受抑有关;survivin可能降低患者生存率。
Objective To investigate the relationship between the expression of survivin and caspase-3 in hepatocellular carcinoma and its adjacent tissues, and to find out the relationship between the two and the relationship between the two and the relationship between the two and to provide a scientific basis for further study on the pathogenesis of liver cancer, early diagnosis and the search for scientific treatment The theoretical basis. Methods The expression of survivin and caspase-3 in hepatocellular carcinoma and its adjacent tissues was observed by immunohistochemistry staining. Combined with the clinicopathological features of the patients, we analyzed the expression of survivin and caspase-3. Results The expression of survivin in hepatocellular carcinoma was significantly higher than that in paracancer tissues (P <0.01), but not related to age, sex and AFP (P> 0.05) 3 was higher in HCC tissues than in HCC tissues (P <0.01). The expression of survivin and caspase-3 in HCC tissues was negatively correlated (P <0.05). The survival rate of survivin-positive HCC tissues was lower than that of survivin-negative HCC Patients (P <0.05). Conclusion Survivin can inhibit apoptosis and promote the development of hepatocellular carcinoma. Caspase-3 can promote apoptosis and inhibit the occurrence of hepatocellular carcinoma. Survivin inhibits the apoptosis of cells is related to the inhibition of caspase-3. Survivin may reduce the survival rate of patients.