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目的:对头孢呋辛不良反应报告中不合理用药情况进行分析,为进一步规范临床合理用药提供参考。方法:采用回顾性统计分析方法,对武汉市药品不良反应(ADR)监测中心2009～2010年收集的107份头孢呋辛ADR报告,参考药品说明书等对报告中不合理用药情况进行分析。结果:107例ADR/ADE报告中,给药方法不合理102例(95.33%),超药品说明书中推荐剂量用药28例(26.17%),无指证用药11例(10.28%)。结论:头孢呋辛不合理用药情况较严重,应加强ADR的监测与报告,合理使用头孢呋辛,减少或避免ADR/ADE的发生。
OBJECTIVE: To analyze the unreasonable use of drugs in adverse reactions of cefuroxime in order to provide reference for further regulating the rational use of drugs in clinical practice. Methods: Retrospective statistical analysis was used to analyze 107 cases of cefuroxime ADR collected in ADR monitoring center from 2009 to 2010 in Wuhan City, and the reference drug specification was used to analyze the irrational drug use in the report. Results: In 107 ADR / ADE reports, 102 cases (95.33%) were irrational, 28 cases (26.17%) recommended drugs and 11 cases (10.28%) without drugs. Conclusion: The inappropriate use of cefuroxime is more serious. Monitoring and reporting of ADR should be strengthened. Cefuroxime should be used reasonably to reduce or avoid the occurrence of ADR / ADE.