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目的观察局部应用替硝唑含片治疗牙周炎和冠周炎的临床疗效。方法将80例牙周炎和冠周炎患者随机分为2组,治疗组采用局部应用替硝唑含片疗法,对照组采用口服替硝唑片疗法,比较2组的临床疗效、不良反应发生率。结果治疗组牙周炎总有效率为100.00%,对照组牙周炎总有效率为90.00%,2组差异无统计学意义(χ~2=2.1053,P>0.05)。治疗组冠周炎总有效率为100.00%,对照组冠周炎总有效率为95.00%,2组差异无统计学意义(χ~2=1.0256,P>0.05)。治疗组不良反应发生率为5.00%低于对照组的25.00%,差异有统计学意义(P<0.05)。结论局部应用替硝唑含片治疗牙周炎和冠周炎效果较好,可减少用药后不良反应,局部用药的安全性更高,用药疗效更稳定,治疗过程简单、易操作,值得临床推广。
Objective To observe the clinical effect of topical tinidazole lozenge in the treatment of periodontitis and pericoronitis. Methods Eighty patients with periodontitis and pericoronitis were randomly divided into two groups. The treatment group was treated with tinidazole buccal tablets. The control group was treated with oral tinidazole tablets. The clinical efficacy was compared between the two groups. Adverse reactions occurred rate. Results The total effective rate of periodontitis in treatment group was 100.00%, while the total effective rate of periodontitis in control group was 90.00%. There was no significant difference between two groups (χ ~ 2 = 2.1053, P> 0.05). The total effective rate of periostitis was 100.00% in the treatment group and 95.00% in the control group. There was no significant difference between the two groups (χ ~ 2 = 1.0256, P> 0.05). The incidence of adverse reactions in the treatment group was 5.00% lower than that in the control group (25.00%), the difference was statistically significant (P <0.05). Conclusion The topical tinidazole buccal tablets treatment of periodontitis and pericoronitis better, can reduce adverse reactions after treatment, topical drug safety, medication efficacy more stable, the treatment process is simple, easy to operate, worthy of clinical promotion .