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一些针对流感病毒血凝素的中和抗体主要通过抑制血凝素和宿主细胞表面受体的结合而发挥作用,还有一些中和抗体可以阻止低p H介导的血凝素的构象改变,这种构象改变对膜融合是必须的。总的来说,前一种抗体主要结合在球状HA1的顶端,其针对的毒株特异性不强,而后一种抗体主要结合在HA2的中间,有较强的毒株特异性。在本研究中,我们分析了一种具有广泛中和作用的抗H3N2流感病毒的人源抗体F005-126的表位及功能。对
Some neutralizing antibodies directed against the influenza virus hemagglutinin function primarily by inhibiting the binding of hemagglutinin to host cell surface receptors and some neutralizing antibodies can prevent low p H -mediated conformational changes in hemagglutinin, This conformational change is necessary for membrane fusion. In general, the former antibody mainly binds to the top of globular HA1, which is not specific against the strain, while the latter antibody is mainly bound to the middle of HA2 and has strong strain specificity. In this study, we analyzed the epitope and function of a human antibody, F005-126, against a H3N2 influenza virus with a broadly neutralizing effect. Correct