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目的:探讨超敏CRP(hs-CRP)、半胱氨酸蛋白酶抑制剂C(CysC)联合检测对冠心病患者的意义。方法:收集120例冠心病(Coronary heart disease,CHD)患者(其中不稳定型心绞痛unstablangina,UA 62例,急性冠状动脉综合征AcuteCoronarySyndrome,ACS 48例,)选择60例性别、年龄、居住地等与冠心病组相匹配的正常者为对照组,测定hs-CRP、CysC水平。结果:hs-CRP、CysC水平在正常对照组、稳定型心绞痛组、急性冠状动脉综合征组中依次增高,恢复后hs-CRP比CysC下降的速度更快,CysC在恢复期更能提醒病人的预后情况,冠心病组与正常对照相比有统计学意义(P<0.01),治疗后与治疗前hs-CRP、CysC的浓度相比(P<0.01)差异有显著性。治疗后hs-CRP敏感度分别为20.96%、24.19%;CysC敏感度分别为47.91%、52.08%。结论:hs-CRP、CysC与CHD发生、发展密切相关,联合检测有利于冠心病的早期诊断。对于临床的分型和病情的发展及预后的观察有极其重要的意义。
Objective: To investigate the significance of combined detection of hs-CRP and CysC in patients with coronary heart disease. Methods: A total of 120 patients with coronary heart disease (CHD) were enrolled in this study. Among them, 60 cases of gender, age, place of residence, and other factors were selected from 62 patients with unstable angina pectoris unstable angina (UA), 62 patients with UA, 48 patients with acute coronary syndrome (ACS) Coronary heart disease matched normal control group, hs-CRP, CysC levels. Results: The levels of hs-CRP and CysC increased in turn in normal control group, stable angina pectoris group and acute coronary syndrome group. The recovery of hs-CRP was faster than that of CysC, and CysC could remind the patients Prognosis, coronary heart disease group compared with the normal control group was statistically significant (P <0.01), after treatment and before treatment hs-CRP, CysC concentration (P <0.01) difference was significant. The sensitivity of hs-CRP after treatment was 20.96% and 24.19% respectively; the sensitivity of CysC was 47.91% and 52.08% respectively. Conclusion: The occurrence and development of hs-CRP and CysC are closely related to the occurrence and development of CHD. Combined detection is beneficial to the early diagnosis of coronary heart disease. For clinical classification and the development of the disease and prognosis of the extremely important significance.