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目的通过对以往青海地区链霉素治疗鼠疫病例单独和联合使用抗生素疗效的比较和分析,探索合理使用新型抗生素治疗鼠疫病例的新方法。方法回顾性调查分析以往鼠疫病例,以年龄、病型、链霉素总用量、链霉素治疗时间为指标,对链霉素单独和联合应用治疗鼠疫病例的疗效进行比较和分析。采用SPSS 10.0软件进行有关统计学分析。结果链霉素单独和联合应用治疗腺鼠疫,在链霉素总用量和治疗时间上有差别,经统计学检验差异有统计学意义;治疗肺鼠疫差异无统计学意义。结论链霉素与环丙沙星联合应用治疗腺鼠疫时,可以降低链霉素的用量和缩短治疗时间;但治疗肺鼠疫时,链霉素的用量和缩短治疗时间无明显差异。
Objective To explore the new methods of rational use of new antibiotics in the treatment of plague cases by comparing and analyzing the curative effect of streptomycin treated plague in Qinghai alone and in combination. Methods Retrospective investigation and analysis of the past plague cases, the age, disease type, the total amount of streptomycin, streptomycin treatment time as an indicator of the effect of streptomycin alone and combined treatment of plague cases were compared and analyzed. Using SPSS 10.0 software for statistical analysis. Results Streptomycin alone and in combination treatment of bubonic plague in the total amount of streptomycin and treatment time differences, the statistical test was statistically significant difference; the treatment of pneumonic plague no significant difference. Conclusion The combination of streptomycin and ciprofloxacin can reduce the dosage of streptomycin and shorten the treatment time when treated with streptomycin. However, there is no significant difference in the dosage of streptomycin and the shortened treatment time in the treatment of pneumonic plague.